Biological and cytogenetic effects of mycotoxins

Deari, Zebibe and Velickova, Nevenka (2022) Biological and cytogenetic effects of mycotoxins. In: V simpozij ALISZP u BiH sa međunarodnim učešćem, 13-15 May 2022, Neum, BiH.

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Abstract

Introduction: Mycotoxins are a group of chemically diverse secondary metabolites that exhibit a wide array of biological effects. Some of the mycotoxins can be mutagenic, carcinogenic, embryo-toxic, nephro-toxic, teratogenic, oestrogenic or immunosuppressive agents. Mycotoxins are secondary metabolites of moulds that exert toxic effects on animals and humans. The toxic effect of mycotoxins on animal and human health is referred to as mycotoxicosis, the severity of which depends on the toxicity of the mycotoxin, the extent of exposure, age and nutritional status of the individual and possible synergistic effects of other chemicals to which the individual is exposed. Acute mycotoxicoses can cause serious and some times fatal diseases. Material and methods: Micotoxins have been extensively studied with respect to their mechanisms of action, including their mutagenic and carcinogenic activity. Cytogenetic methods known today (SCE, CA and MN) as short-term genotoxicity tests and used to determine whether a chemical substance is genotoxic. These tests can be performed both in vitro in human peripheral lymphocytes and in bone marrow cells of in vivo test in animals. This review covers only the human aspects of the untoward effects of mycotoxins.
Results and disscusions: More than 50 articles on investigation of genotoxic effects of mycotoxins were found. All of the study, confrme that carcinogenic mycotoxins are known to cause cancer through genetic damage. In these studies, it was reported that mycotoxins that are likely to be genotoxic carcinogens are aflatoxin B1, sterigmatocystin, luteoskyrin, ochratoxin A, azaserine, mitomycin C, and actinomycin. Knowing the genotoxic effects of a mycotoxin ensures the explanation of the disease molecular levels. Conclusions: With accordance to carcinogenic effects of mycotoxins, these can cause mutations in genetic structure by showing genotoxic effects. Cytogenetic biomarkers can be used as outcome measures of genotoxicity cause by mycotoxins.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine
Divisions:	Faculty of Medical Science
Depositing User:	Nevenka Velickova
Date Deposited:	22 Aug 2022 09:15
Last Modified:	22 Aug 2022 09:15
URI:	https://eprints.ugd.edu.mk/id/eprint/30067

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