The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi, Nicoleta Bianca and Eftimie Totu, Eugenia and Fifere, Adrian and Ardeleanu, Valeriu and Mocanu, Veronica and Mircea, Cornelia and Isildak, Ibrahim and Smilkov, Katarina and Cărăusu, Elena Mihaela (2021) The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis. Antioxidants.

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Abstract

Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential
challenge for public health, with a negative impact on the geriatric patient’s quality of life. The
pathophysiology is not fully known; therefore, no specific treatment has been found to date. The
increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce
the risk factors and detect those with a protective role in this context. The destructive effects of free
radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors,
the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The
evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors
reveal the importance of maintaining a redox balance for the joints and the whole body’s health,
emphasizing the importance of an individualized therapeutic approach based on antioxidant effects.
This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in
KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that
could establish the premises for appropriate treatment to restore the redox balance and improve the
condition of patients with KOA

Item Type:	Article
Subjects:	Natural sciences > Biological sciences Natural sciences > Chemical sciences Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Katarina Smilkov
Date Deposited:	21 Oct 2021 09:27
Last Modified:	21 Oct 2021 09:27
URI:	https://eprints.ugd.edu.mk/id/eprint/28609

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