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Antioxidants
Volume 10
Issue 6
10.3390/antiox10060985
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The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

by
Nicoleta Bianca Tudorachi
1,
Eugenia Eftimie Totu
2,*,
Adrian Fifere
3,*,
Valeriu Ardeleanu
1,
Veronica Mocanu
4,
Cornelia Mircea
4,
Ibrahim Isildak
5,
Katarina Smilkov
6 and
Elena Mihaela Cărăuşu
7
1
Faculty of Medicine, “Ovidius” University of Constanța, Mamaia Boulevard 124, 900527 Constanța, Romania
2
Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1–5 Polizu Street, 011061 Bucharest, Romania
3
Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
4
Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania
5
Faculty of Chemistry-Metallurgy, Department of Bioengineering, Yildiz Technical University, Istanbul 34220, Turkey
6
Faculty of Medical Sciences, Division of Pharmacy, Department of Applied Pharmacy, Goce Delcev University, Krste Misirkov Street, No. 10-A, 2000 Stip, North Macedonia
7
Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, “Nicolae Leon” Building, 13 Grigore Ghica Street, 700259 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Maria-Jose Alcaraz
Antioxidants 2021, 10(6), 985; https://doi.org/10.3390/antiox10060985
Received: 16 May 2021 / Revised: 11 June 2021 / Accepted: 17 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue Biological Activity of Mammalian Metabolites of Antioxidants)
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Abstract

Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA. View Full-Text
Keywords: oxidative stress; ROS; antioxidants; pathophysiology; KOA; cellular senescence; apoptosis oxidative stress; ROS; antioxidants; pathophysiology; KOA; cellular senescence; apoptosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Tudorachi, N.B.; Totu, E.E.; Fifere, A.; Ardeleanu, V.; Mocanu, V.; Mircea, C.; Isildak, I.; Smilkov, K.; Cărăuşu, E.M. The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis. Antioxidants 2021, 10, 985. https://doi.org/10.3390/antiox10060985

AMA Style

Tudorachi NB, Totu EE, Fifere A, Ardeleanu V, Mocanu V, Mircea C, Isildak I, Smilkov K, Cărăuşu EM. The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis. Antioxidants. 2021; 10(6):985. https://doi.org/10.3390/antiox10060985

Chicago/Turabian Style

Tudorachi, Nicoleta B., Eugenia E. Totu, Adrian Fifere, Valeriu Ardeleanu, Veronica Mocanu, Cornelia Mircea, Ibrahim Isildak, Katarina Smilkov, and Elena M. Cărăuşu 2021. "The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis" Antioxidants 10, no. 6: 985. https://doi.org/10.3390/antiox10060985

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