Evrosimovska, Biljana and Veleska-Stefkovska, Daniela and Dimova, Cena and Menceva, Zaklina (2020) Second generation platelet concentrate (platelet-rich fibrin) in its application in oral surgery. Journal of Hygienic Engineering and Design, 31. pp. 145-151. ISSN 1857- 8489
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Abstract
The development of bioactive surgical additives,
which are being used to regulate the inflammation
and increase the speed of healing process, is one of
the great challenges in oral surgery. Platelet-rich fibrin
(PRF) is a second-generation platelet concentrate who
was defined as an autologous leukocyte and PRF biomaterial, in which, platelets and leukocytes are collected with high efficiency such that the growth factors
will able to release gradually during at least 1 week.
The biologic effect of this fibrin matrix is: angiogenesis,
immune control, harnessing the circulating stem cells,
and wound protection by epithelial cover. The following article attempts to summarize our clinical cases
regarding the technique of using PRF, focusing on its
preparation, advantages of using it in oral surgery.
Three cases with different clinical diagnoses were taken for this study in order to show the possible ways
of application of PRF in the surgical field. In the first
case, it is a 53 year-old female patient who has been
diagnosed with osteonecrosis of the alveolar ridge
during the examination in the projection of the first
lower right molar. In the second case, PRF application
was administered to a 41 year-old female patient diagnosed with radicular cyst on the upper left second
incisor. The third case involved a 47 year-old male patient with diagnosed gangrenous roots in the upper
right first and second premolars ant the second molar
in which the PRF application was intended to achieve
alveolar bridge augmentation. PRF was prepared with
blood drawn from individuals using technique du to
PRF protocol. Both types of PRF (I and A-PRF) were
applied independently in the first case, and in the second and third cases a bone graft was placed together
with PRF.
The soft and bone tissue management in all our cases
show process of neovascularization through the PRF
clot and the epithelial covering development. In spite
of the infectious and inflammatory statement of such
sockets, rapid healing of the wound was observed
without pain, dryness, or purulent complications. The
results of the observed cases showed that biologic
effect of PRF was revealed trough achieved angiogenesis, immune control, harnessing the circulating stem
cells, and wound protection by epithelial cover.
PRF alone or in combination with other biomaterials
seems to have several advantages and indications in
oral surgery, due it is a minimally invasive technique
with low risks and satisfactory results.
Key words: Platelet-rich fibrin, Blood platelet, Bone
regeneration, Soft tissue regeneration.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Cena Dimova |
| Date Deposited: | 14 Jul 2020 15:47 |
| Last Modified: | 14 Jul 2020 15:47 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/24203 |
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