Electrochemical evaluation of the mechanisam of oxidation of capsaicin and its dependence of different pH values of the medium

Maksimova, Viktorija and Mirceski, Valentin and Koleva Gudeva, Liljana and Gulaboski, Rubin (2015) Electrochemical evaluation of the mechanisam of oxidation of capsaicin and its dependence of different pH values of the medium. In: SOE DAAD Workshop 2015, 17-21 Sept 2015, Ohrid, Macedonia.

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Abstract

Capsaicin is a well-known alkaloid which can be isolated from hot peppers (Capsicum sp. L). It is composed from vanylil moiety and alkenyl chain connected through an amide group. This structure undergoes to a characteristic oxidation process which was examined in our experiment. Redox mechanism of capsaicin was assessed in different buffer medium with pH values 3.6-10.5, by the means of cyclic voltammetry on a glassy carbon electrode. Cyclic voltamograms showed that in the first scan only one oxidation peak has occurred on Ipa= 0.42 V but in the second scan another oxidation peak Ipa= 0.22 V was observed for capsaicin (50 µmol/L).
It was supposed that in the first anodic oxidation peak capsaicin is donating two electrons, which is leading to the formation of phenoxonium cation, and the second one is due to hydrolysis of the cation to o-benzoquinone. This hydrolysis was not observed in alkaline conditions, which demonstrate that this process is pH dependent reaction.
Electrochemical evaluation of the mechanism of oxidation of capsaicin can help in understanding of the biological redox processes, not only for capsaicin, but also for some other polyphenolic compounds. This data can be applied in prospecting the antioxidative or antiradical activities and chemoprotective properties of capsaicin and many other similar molecules.

Item Type:	Conference or Workshop Item (Lecture)
Subjects:	Agricultural Sciences > Agricultural biotechnology Medical and Health Sciences > Basic medicine
Divisions:	Faculty of Medical Science
Depositing User:	Rubin Gulaboski
Date Deposited:	28 Sep 2015 11:22
Last Modified:	28 Sep 2015 11:22
URI:	https://eprints.ugd.edu.mk/id/eprint/13864

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