An ethno - pharmacological and toxicological review of Ecballium Elaterum (L.)A. Rich

Bauer, Biljana and Kavrakovski, Zoran and Kostik, Vesna (2013) An ethno - pharmacological and toxicological review of Ecballium Elaterum (L.)A. Rich. In: International conference on natural products utilization from plants to pharmacy shelf (ICNPU), 3-6 Nov 2013, Bansko, Bulgaria.

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Ecballium elaterium (L.) A. Rich. (also known as squirting or exploding cucumber) is a weedy plant that belongs to the Cucurbitaceae family. The roots and juice of its fruits were used in our traditional medicine against rheuma and sinusitis.This plant , and especiallu its fruit, is poisonous. The work reviews and analyses the traditional use, biological activities with the corresponding chemical constituents, and toxicological data on Ecballium elaterium species. Data regarding squirting cucumber was collected using electronic databases and library search for selected peer-reviewed articles. Additional information on traditional use and botany was obtained from published books. The review encompasses literature, mainly regarding biological activity and toxicological data, from 1950 to 2013. Ecballium elaterium has been used in Asian and European traditional medicine mainly against inflammation, treatment of epilepsy, treatment of malaria, rhino- sinusitis in various forms. In vivo and in vitro testing of plant extracts and isolated compounds determine diverse biological activities including anti-inflammatory and anti-hepatotoxic activity. Cucurbitacin B from the Ecballium elaterium has a significant anti-inflammatory activity and preventive and curative effects against CCl4 – induced hepatic-toxicity. Immuno-modulatory activity was observed on cucurbitacin E isolated from Ecballium elaterium. Squirting cucumber contains various cucurbitacins, which cause diarrhea and enteritis. In the ancient world it was considered to be abortifacient. Ecballium elaterium may have the potential to induce genotoxicity, allergic reactions, renal and hearth failure, keratoconjuctivitis and well-defined edematous areas in the eyes.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Vesna Kostik
Date Deposited: 26 Jan 2015 11:54
Last Modified: 26 Jan 2015 11:54

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