Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer’s pathology

Maj, Magdalena and Ilhan, Aysegul and Neziri, Dashurie and Gartner, Wolfgang and Berggard, Tord and Attems, Johannes and Base, Wolfgang and Wagner, Ludwig (2011) Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer’s pathology. World Journal of Diabetes, 2 (4). pp. 49-53. ISSN 1948-9358

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Abstract

Frequent concomitant manifestation of type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) has been recently demonstrated by epidemiological studies. This might be due to functional similarities between β-cells and neurons, such as secretion on demand of highly specific molecules in a tightly controlled fashion. An additional similarity represents the age-related alteration of hyperphosphorylated tau in AD patients. Similarly, alterations have been identified in β-cells of T2DM patients. The islet amyloid polypeptide has been associated with β-cell apoptosis. As a consequence of increasing age, the accumulation of highly modified proteins together with decreased regenerative potential might lead to increasing rates of apoptosis. Moreover, reduction of β-cell replication capabilities results in reduction of β-cell mass in mammals, simultaneously with impaired glucose tolerance. The new challenge is to learn much more about age-related protein modifications. This can lead to new treatment strategies for reducing the incidence of T2DM and AD.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Kosturanova
Date Deposited: 06 Mar 2013 11:54
Last Modified: 06 Mar 2013 11:54
URI: http://eprints.ugd.edu.mk/id/eprint/5746

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