Freeze dried kit formulation of trastuzumab-immunoconjugates

Sterjova, Marija and Janevik-Ivanovska, Emilija and Apostolova, Paulina and Dzodic, Predrag (2017) Freeze dried kit formulation of trastuzumab-immunoconjugates. In: 17th CEEPUS Symposium and Summer School on Bioanalysis.

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Abstract

Trastuzumab is a humanized anti-HER2 monoclonal antibody used for therapy of metastatic breast cancer. Conjugated antibodies with toxins, drugs and radionuclides, provide high hope for development of cancer-specific cytotoxic reagents. The formulation of stable immunoconjugates with a bifunctional chelators (BFCA) is required in order to obtain successful radiolabeling. The aim of this examination was to development a stable freeze dried trastuzumab immunoconjugates with BFCA p-SCN-Bn-DTPA, p-SCN-Bn-DOTA, 1B4M-DTPA.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Marija Arev
Date Deposited: 24 Aug 2017 08:01
Last Modified: 24 Aug 2017 08:03
URI: http://eprints.ugd.edu.mk/id/eprint/18085

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