Pavlovska, Gorica and Darkovska-Serafimovska, Marija (2011) Rapid determination of Valsartan in pharmaceutical dosage forms by HPLC. In: Euroanalysis XVI, 2011, Belgrade, Serbia.
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Abstract
Valsartan is a drug that lowers blood pressure and is as effective as enalapril, lisinopril and amlodipine in the treatment of mild to moderate hypertension. Valsartan is available as tablets for oral administration, containing 40 mg, 80 mg, 160 mg or 320 mg of valsartan. Literature survey revealed that valsartan is not yet official in any of the pharmacopoeia. There are various analytical methods with UV, HPLC, LC-MS and other analytical techniques for determination of valsartan. In recent years many methods have been developed for the determination of valsartan in pharmaceutical dosage forms based on HPLC. The focus of present study was to develop and validate a rapid and economical HPLC method for the determination of valsartan in tablet dosage form.
It is proposed new method for the determination of valsartan in pharmaceutical dosage forms. Experimentally are determined the optimal chromatographic conditions, the optimal medium and optimal time for sampling. The proposed method is validated according to ICH regulations. The following parameters are determined: specificity, linearity, range, limit of detection, limit of quantification, precision and accuracy. In its method range there is great linearity with correlation coefficient R=0,999, limit of detection LOD=1,7 μg/mL and limit of quantification LQD=5,1 μg/mL. The method is characterized by high accuracy which is determined by three standard additions to the placebo. Repeatability and intermediate precision are determined. The% RSD values for ripitability, intraday and interday precision were <1%. The retention time is 2,7 min and the method is very simple and quick.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Marija Darkovska-Serafimovska |
| Date Deposited: | 24 Oct 2013 08:11 |
| Last Modified: | 24 Oct 2013 08:11 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/7699 |
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