The role of alpha-fetoprotein (AFP) in prenatal screening

Velickova, Nevenka and Nikolov, Vlatko and Sterjovska-Aleksovska, Andrijana and Sumanov, Gorgi (2013) The role of alpha-fetoprotein (AFP) in prenatal screening. 3rd Congress of Gynecologists and Obstetricians of Macedonia with International Participation-Book of Lectures and Abstracts. ISSN 978-9989-37-028-1

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Abstract

Introduction: AFP is encoded by the AFP gene, located on the q-arm of chromosome 4 (4q25). AFP levels increase during pregnancy. At the end of the 1-st trimester, fetal AFP levels decrease. Normal adult levels are usually achieved by 8 to 12 months of age. In pregnancy, AFP is analyzed from maternal blood or amniotic fluid as a screening test for chromosomal abnormalities, as principally increased in open neural tube defects and decreased in Down syndrome.

Item Type: Article
Uncontrolled Keywords: alpha-fetoprotein, prenatal screening, chromosomal abnormalities, PRISCA software
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Andrijana Sterjovska Aleksovska
Date Deposited: 24 Oct 2013 14:26
Last Modified: 24 Oct 2013 14:26
URI: https://eprints.ugd.edu.mk/id/eprint/7657

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