Simeonovska Joveva, Elena and Karakolevska Ilova, Marija and Serafimov, Aleksandar and Petrovski, Stefan and Skenderi, Viollca (2013) Paraneoplastic disorders affecting the neuromuscular junction: Myastenia gravis associated with paraneoplastic syndrome - case report. Medicus 2013, Tetovo, 61 (18(1)). pp. 146-149. ISSN 1409-6366UPC
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Abstract
Paraneoplastic neurologic disorders can affect any part of the nervous system. Rarely, the motor neuron or motor axons may be affected in patients with cancer , leading to clinical signs and symptoms that resemble ALS. Myasthenia gravis (MG) is the prototypic autoimmune disorder of the nervous system. In most cases ,MG is an idiopathic disorder, and the events leading to the production of acetylcholine receptor autoantibodies are not known. About 15% of the patients have a paraneoplastic form of MG associated with a thymic neoplasm ( thymoma ).Patients with paraneplastic MG typically have late-onset generalized MG and require long –term immunosuppression. Another form of neuromuscular junction disorder , the Lambert- Eaton myasthenic syndrome, often occurs a as a paraneoplastic manifestation of small cell lung cancer. Together, MG and Lambert-Eaton syndrome are the most common paraneoplastic neurologic disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Paraneoplastic neurologic disorders. Myasthenia gravis, thymoma ,long term immunosuppression. |
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elena Joveva |
| Date Deposited: | 26 Jul 2013 09:05 |
| Last Modified: | 05 Nov 2013 11:58 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/6843 |
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