Gulaboski, Rubin and Koleva Gudeva, Liljana and Ivanova, Violeta and Kostadinovic Velickovska, Sanja (2013) Metal binding and antioxidative properties of novel Coenzyme Q-0 derivatives. [Project]
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Abstract
Many organic compounds having a benzoquinone structure show diversity of physiologically important properties and they are explored as antitumor, antibacterial, and antioxidative systems. Benzoquinones are seen as irreplaceable chemicals in pharmaceutical industry since they are explored as starting materials in synthesis of many drugs and natural products. The 2,3-dimethoxy-5-methyl-p-benzo-quinone (Coenzyme Q-0) is a valuable starting material used for the synthesis of vitamin E and Coenzyme Q-10. Vitamin E and Coenzyme Q-10 exhibit plethora of important physiological function, and they are crucial compounds involved in the mitochondrial electron transfer chain, while providing conditions for ATP synthesis. Most of the benzoquinones containing OH groups in their structure are recognized as efficient antioxidants. Many of these are prepared by oxidation of phenols or some methoxy derivatives of benzene. In our recent Patent we have shown that we can synthesize hydroxyl benzoquinones in a very cheap manner, while producing powerful antioxidants and metal-ions ligands from methoxy benzoquinones as starting material. The aim of this project is to investigate the structures and the properties of the derivatives obtained by reaction of Coenzyme Q-0 in alkaline media. Our main focus will be on studying the metal binding and antioxidative properties of created derivatives. As a main instrumental toll we will use electrochemical and HPLC techniques, coupled with electronic paramagnetic resonance. Revealing the features of synthesized derivatives will help in producing of cheap and efficient antioxidants and ligand that can be used for pharmaceutical, medical and chemical purposes.
| Item Type: | Project |
|---|---|
| Uncontrolled Keywords: | coenzyme Q, antioxidants, hydroxylation, reactive oxygen species, voltammetry |
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Chemical sciences |
| Divisions: | Faculty of Agriculture |
| Depositing User: | Rubin Gulaboski |
| Date Deposited: | 15 May 2013 14:13 |
| Last Modified: | 30 Jan 2024 10:53 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/6276 |
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