Gjorgjeska, Biljana (1991) Simultaneous determination of polythiazide and prazosin in tablets by second-order derivative UV spectroscopy. International Journal of Pharmaceutics, 70. pp. 187-190. ISSN 0378-5173
Full text not available from this repository.Abstract
Abstract
A second-derivative spectroscopic method for the simultaneous determination of polythiazide and prazosin in tablets was developed. Solutions of these tablets in 0.2 N methanolic hydrochloric acid were analyzed by measurement of the amplitudes of the positive peak at 356 nm with respect to the negative peak at 346 nm for prazosin, and the amplitude of the positive peak at 236 nm with respect to the baseline for polythiazide. Confirmation of the technique was established using HPLC. The use of derivative spectroscopy in this manner provides a specific, rapid and accurate determination of the binary mixture in the tested concentration range of 1–10 μg/ml for polythiazide and 1–20 μg/ml prazosin.
Keywords
Polythiazide; Prazosin; Simultaneous determination; Second-derivative UV spectroscopy
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Natural sciences > Chemical sciences Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Biljana Gorgeska |
| Date Deposited: | 29 Apr 2013 12:28 |
| Last Modified: | 03 Jun 2013 07:45 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/6180 |
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