Resuscitation after prolonged cardiac arrest: effects of cardiopulmonary bypass and sodium - hydrogen exchange inhibition on myocardial and neurological recovery

J. Liakopoulos, Oliver and Hristov, Nikola and D. Buckberg, Gerald and Triana, Jonathan and Trummer, Georg and S. Allen, Bradley (2011) Resuscitation after prolonged cardiac arrest: effects of cardiopulmonary bypass and sodium - hydrogen exchange inhibition on myocardial and neurological recovery. European Journal of Cardio-thoracic Surgery (40). pp. 978-984.

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Abstract

Objective: To determine if cardiopulmonary bypass (CPB), together with inhibition of the sodium—hydrogen exchanger (NHE), limits
myocardial and neurological injury and improves recovery after prolonged (unwitnessed) cardiac arrest (CA), as NHE inhibition improved
recovery after deep hypothermic circulatory arrest. Methods: Twenty-seven pigs (31—39 kg) underwent 15 min of prolonged (no-flow) CA
followed by 10 min of cardiopulmonary resuscitation-advanced life support (CPR-ALS). Subjects with restoration of spontaneous circulation
(ROSC) during CPR-ALS received either no drug (n = 6) or an inhibitor of the NHE (HOE-642; n = 5). In the 16 unsuccessfully resuscitated animals,
peripheral normothermic CPB was instituted, and either no drug (n = 9) or similar HOE-642 (n = 7) therapy started. Hemodynamic data, a speciesspecific
neurological deficit score (0 = normal to 500 = brain death), and mortality were recorded at 24 h, and biochemical variables of organ
injury measured. Results: CPR-ALS restored ROSC in 41% (11/27) of animals, but was unsuccessful in 59% (16/27) that required CPB. Without CPB,
HOE-642 increased cardiac index and decreased vascular resistance; with CPB, HOE-642 caused higher pump flows (3.4 +- 0.6 l min^-1 m^-2 vs
2.5 +- 0.7 l min^-1 m^-2; p < 0.001) and higher post-arrest cardiac index; but animals required more vasopressors ( p = 0.019) from drug-induced
vasodilation. No differences between biochemical markers of oxidative and organ injury and overall 24-h mortality (20%) were found between
groups. Neurological score was improved at 24 h compared with 4 h only after HOE-642 treatment with (150 +- 34 vs 220 +- 43; p = 0.003) or
without CPB (162 +- 39 vs 238 +- 48; p <= 0.001), but failed to reach statistical difference with respect to the untreated group. Conclusions: CPB is
an effective resuscitative tool to treat prolonged CA but there is limited improvement of neurological function. NHE inhibition augments cardiac
and neurological function, but its effect was less pronounced than in other studies.

Item Type: Article
Uncontrolled Keywords: Cardiac arrest; Cardiopulmonary resuscitation; Cardiopulmonary bypass; Sodium—hydrogen exchanger (NHE) inhibition
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Mirjana Kocaleva
Date Deposited: 19 Mar 2013 16:32
Last Modified: 19 Mar 2013 16:32
URI: https://eprints.ugd.edu.mk/id/eprint/5916

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