Can neuron-specific enolase and S100 markers evaluate neuro-damage from sevoflurane in children?

Sevoflurane, a commonly used inhalation anesthetic agent in pediatric surgery, has revolutionized the field of anesthesia by providing a safe and effective means of rendering unconscious children during surgical procedures. However, amid the benefits it offers, concerns have emerged regarding its potential neurotoxicity, particularly in developing brains. This has prompted the exploration of novel methods to evaluate neuro-damage in pediatric patients exposed to sevoflurane.

In this article, we delve into the intriguing possibility of employing Neuron-Specific Enolase (NSE) and S100 markers as diagnostic tools for assessing neuro-damage resulting from sevoflurane exposure in children. These biomarkers, found in blood and cerebrospinal fluid, hold promise in shedding light on the intricate relationship between sevoflurane anesthesia and potential neurological effects. To comprehend this subject fully, it is imperative to explore the background of sevoflurane in pediatric anesthesia, understand the significance of NSE and S100 markers, review pertinent research findings, and consider the practical implications in clinical settings.