Ehogenicity of thyroid gland on ultrasonography in primary hypothyroidism

Krstevska, Branka and Velkoska Nakova, Valentina and Dimitrovski, Chedo and Jovanovska Misevska, Sasha and Pemovska, G. and Adamova, K. (2011) Ehogenicity of thyroid gland on ultrasonography in primary hypothyroidism. Mak Med Pregled, 65 (1). pp. 26-30. ISSN 0025-1097

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Background. The aim of this study was to investigate
the association between echogenicity of thyroid gland
and low thyroid function.
Methods. The study group included 60 patients, with normal
and low thyroid function, who visited the Outpatient
Department of the Clinic of Endocrinology, Diabetes
and Metabolic Disorders in the period from April
2008 to October 2009. Echogenicity of the thyroid gland
in all patients was evaluated by ultrasonography as well
as serum concentrations of TSH, fT4 and thyroid autoantibody
(anti-TPO). To find out the association between
thyroid ehogenicity with mean TSH and anti-TPO in different
ages, we divided the patients into five subgroups
according to age.
Results. Patients with decreased echogenicity had a higher
mean TSH compared with patients with normal echogenicity
(2.77 mIU/l vs. 1.75 mIU/l) (p=0.04). Differences
were more significant in patients with markedly
decreased echogenicity (6.34 mIU/l vs. 1.75 mIU/l) (p<
0.0001). Patients with reduced echogenicity had a higher
risk of having anti-TPO than patients without normal
echogenicity (p<0.001). This association was stronger
when echogenicity was markedly decreased. According to
age, only younger population (19-29 years) with decreeased
and markedly decreased echogenicity had significantly
higher mean TSH and anti-TPO values.
Conclusions. Thyroid ultrasonography changes can be
used as an early sign of low thyroid function, especially in
younger population.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Valentina Velkovska
Date Deposited: 17 Dec 2012 14:38
Last Modified: 24 Oct 2014 10:41

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