Correlation of Blood Fibrinolytic Activity and Clinical Outcome After Oral Surgery Interventions

Dimova, Cena and Andonovska, Biljana and Neceva, Violeta and Kovacevska, Ivona and Georgiev, Zlatko (2009) Correlation of Blood Fibrinolytic Activity and Clinical Outcome After Oral Surgery Interventions. Balk J Stom, 13 (2). pp. 111-116. ISSN 107-1141

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The primary aim was to investigate how the oral surgical interventions,
as psychophysical and operative trauma, influence the response of the blood
fibrinolytic system, and whether the possible changes in the level of the
activators and inhibitors of the fibrinolytic system could correlate to clinical
results. Fourthly healthy subjects with operative tooth extractions were
included in the research; 35 subjects, blood donors, constituted a control
group. The influence of the interventions over the parameters of the blood
fibrinolytic system was examined prior to surgery and immediately after
the extraction with Elisa test. The values of the blood pressure and pulse
frequency prior to the surgery; after the applying of the local anaesthesia
and immediately after the performed interventions were the only objective
parameters for the evident physical reflections of the stress. At the control
investigations, after 24, 48, hours and seven days, certain changes like oedema,
haematoma, pain and dry socket have been presented.
Decreased values of t-Pa and PAI-1 after the oral surgery were found
at a high statistically significant difference. The analysis of diastolic blood
pressure and pulse frequency values showed statistic significance, showing
psychological dimension of oral surgery. There was a positive correlation
between most of the parameters from the control examinations and the
parameters (t-Pa, PAI-1, pro-activators and inhibitors) of the fibrinolytic
system in the examined group.
Oral surgical intervention, as a stress factor, had influence and affects
the fibrinolytic process through the effect upon pro-activators and inhibitors
of the fibrinolytic system, and severity of the clinical outcome after tooth
extraction. Parameters of fibrinolytic system, t-PA and PAI-1, can be the
most sensitive markers of reaction to oral surgical stress.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Cena Dimova
Date Deposited: 05 Nov 2012 09:56
Last Modified: 30 Sep 2013 11:07

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