Method Optimization for Ketoprofen Tablet Dissolution: Enhanced Efficiency Through Modified Test Conditions

The continuous advancement of the pharmaceutical industry is not only marked by the discovery of novel
therapeutic agents and innovative dosage forms but also by the need to improve existing analytical methodologies,
especially those involved in process quality control. In modern pharmaceutical development, rapid, cost-effective,
and reliable analytical techniques are essential to ensure the consistent performance and therapeutic efficacy of
marketed drug products. One of the critical parameters in evaluating the bioavailability and therapeutic potential of
solid oral dosage forms is their dissolution behavior, which directly correlates with drug solubility under
physiologically relevant conditions. This research paper focuses on the optimization and modification of an existing
UV-Vis spectrophotometric method for testing the dissolution of ketoprofen in tablet formulations, with the goal of
simplifying and accelerating the dissolution testing protocol. The study involved the deliberate modification of
several test conditions, including the pH of the dissolution medium (adjusted from pH 7.2 to pH 6.8), the rotation
speed (reduced from 100 rotations per minute (rpm) to 75 rpm), and the sampling time points (shifted from a single
45 minute time point to three intervals of 15, 30, and 45 minutes). The choice of these parameters was based on their
relevance to both physiological conditions and analytical efficiency. The results demonstrated that the modified
method produced more favorable dissolution profiles, with significantly improved average solubility of the active
pharmaceutical ingredient (API) even after just 15 minutes of testing. Such a rapid and consistent dissolution rate
not only ensures better prediction of in vivo behavior but also offers a practical advantage for routine quality control
testing by reducing analysis time without compromising reliability. Furthermore, this study highlights the need for
ongoing evaluation and refinement of existing pharmacopoeia methods, recognizing that established procedures may
benefit from scientifically supported improvements. The findings support a more flexible approach to method
development, where alternative techniques when properly validated in line with official pharmacopeia standards can
be considered for routine use. The study also emphasizes the broader relevance of method optimization in
pharmaceutical analysis, demonstrating how minor but deliberate modifications to test conditions can lead to
meaningful improvements in accuracy, speed, and efficiency. In conclusion, the proposed dissolution testing method
presents a viable and promising alternative for the routine analysis of ketoprofen tablets, offering enhanced
operational efficiency, practical utility, and alignment with modern industry demands for rapid, reliable, and cost-effective quality control strategies.