Cvetkovski, Aleksandar (2024) Quantum Chemical calculations of lattice energy for Clopidogrel picrate pseudopolymorphs. In: COST CA 22107 BEST-CST Project Meeting, 25-26 May 2024, Zagreb, Croatia.
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Abstract
The purpose of engineering multicomponent crystals of drug model Clopidogrel, potent antiplatelet drug, marketed as hydrogen sulfate salt
(ClopH+•HSO4
−) in Plavix® (BMS-Sanofi), encompassed cocrystallization screening of clopidogrel deprotonated (free) base with coformers from the
range of organic acids. The reported crystal structures relate to obtained two pseudopolymorphic forms of S(+)clopidogrel–picrate. Form 1 crystallizes in
the monoclinic space group P21 with an ionic couple S(+)ClopH+•Pic− and a molecule of solvent ethanol in the asymmetric unit, while Form 2
crystallizes in the monoclinic space group C2 with two ionic couples in the asymmetric unit. The configurations and conformations of the ionic couples,
held together by ionized +N-H···O hydrogen bonds, are nearly identical in the structures. [1]
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Engineering and Technology > Chemical engineering Natural sciences > Chemical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Aleksandar Cvetkovski |
| Date Deposited: | 15 Aug 2025 06:53 |
| Last Modified: | 15 Aug 2025 06:54 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/36272 |
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