Preparation and characterization of amphiphilic cream formulations with meloxicam

Drakalska, Elena and Arev, Marija and Apostolova, Paulina and Karpicarov, Dino and Maksimova, Viktorija and Miceva, Dijana and Cvetkovski, Aleksandar and Samardziska, Marija (2024) Preparation and characterization of amphiphilic cream formulations with meloxicam. Pharmacia. ISSN 2603-557X

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Abstract

The purpose of this study is to formulate and evaluate amphiphilic cream with meloxicam indicated for topical relief of pain, particularly because there are currently no available topical dosage forms on the market. Thus, the present research is focused on characterization of the capacity of the amphiphilic base, composed of glycerol monostearate, cetyl alcohol, Tagat® S2, Myritol® 318, propylene glycol, and white petrolatum, to be loaded with drug model meloxicam dissolved in propylene glycol. To enhance the solubility and penetration of meloxicam, menthol as a rubefacient was added to the meloxicam solution. The series of three formulations were prepared with variable content of added menthol. Obtained creams were characterized by drug content, pH, spreadability, viscosity, microbial purity, drug release, and stability. Results showed stable cream formulations with good spreadability and viscosity, suitable for topical application.

Item Type:	Article
Impact Factor Value:	1,1
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Elena Drakalska Sersemova
Date Deposited:	26 Nov 2024 10:51
Last Modified:	26 Nov 2024 10:51
URI:	https://eprints.ugd.edu.mk/id/eprint/35071

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