Cost-effectiveness of combination LMWHs/UFH versus UFH/LMWHs for the prevention of postsurgical venous thromboembolism at orthopedic department in Clinical Hospital Stip

Lazarova, Biljana and Naumovska, Zorica and Kapedanovska, Aleksandra and Sterjev, Zoran and Suturkova, Ljubica (2020) Cost-effectiveness of combination LMWHs/UFH versus UFH/LMWHs for the prevention of postsurgical venous thromboembolism at orthopedic department in Clinical Hospital Stip. Macedonian Pharmaceutical Bulletin, 66 (Suppl 1) 75 - 76 (2020). ISSN 1857 - 8969

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Abstract

This study aimed to evaluate the cost-effectiveness of thromboprophylaxis with LMWHs vs UFH in the prevention of venous thromboembolism (VTE) after orthopedic surgery from the perspective of the Clinical hospital in Stip. A model was developed that included both acute VTE (represented as a decision tree) and long-term complications (represented as a Markov process with one-year cycles). Transition probabilities were derived from phase III clinical trials comparing LMWHs with UFH and published literature. Unit costs were taken from the official, publically available hospital and health care insurance data and included direct drug costs for VTE (DVT and PE) prophylaxis (UFH/10000 IU and LMWHs/4000 IU) and hospitalization costs (hospital full board, disposables, medical services, concomitant therapy, healthcare professional time). Costs are reported in Macedonian Denars (MKD). When LMWHs and UFH are compared in orthopedic patients, LMWHs dominates UFH and are associated with improved health outcomes, measured by increased quality-adjusted life years (QALYs; 0.05) and with lower cost (savings of 20438.96 MKD) per patient.
LMWHs are a cost-saving alternative to UFH for VTE prophylaxis in patients undergoing orthopedic surgery. Over a one-year horizon, LMWHs dominated UFH in the prevention of VTE events in patients undergoing surgery, providing more quality-of-life benefit at a lower cost.

Item Type:	Article
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Biljana Lazarova
Date Deposited:	30 Sep 2024 11:00
Last Modified:	30 Sep 2024 11:00
URI:	https://eprints.ugd.edu.mk/id/eprint/34747

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