Modelling of binding affinity constants of a potential new class antiparasitic drugs

Cvetkovski, Aleksandar (2024) Modelling of binding affinity constants of a potential new class antiparasitic drugs. In: “Novel leads and drugs for vector borne diseases: Targets and off targets (toxicity and ecotoxicity) and mechanism of action”, 19-20 Sept 2024, Athens, Greece. (Unpublished)

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Abstract

Parasitic protozoa are incapable of de novo synthesis of the purine rings
Biophysical and biochemical characteristics of ADK isolated form Leishmania Donovan are different then ADK from other eukaryotic sources regarding to the mode of action.
T. brucei and Leishmania differences: Adenine amidotransferase, a Leishmania-specific enzyme that does not exist in other studied trypanosomatids or in mammalian cells in deamination of adenine.
In silico molecular modelling based on docking study for testing binding affinity of antiparasitic nucleoside drugs such tubercidin and other lead compounds testing the hypothesis whether ADK of Leishmania is less effective in phosphorylation reaction of nucleoside analogues then TbADK

Item Type:	Conference or Workshop Item (Speech)
Subjects:	Medical and Health Sciences > Basic medicine Engineering and Technology > Chemical engineering Natural sciences > Chemical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Cvetkovski
Date Deposited:	26 Sep 2024 11:01
Last Modified:	26 Sep 2024 11:01
URI:	https://eprints.ugd.edu.mk/id/eprint/34715

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