Modelling of binding affinity of siderophores with redox Fe3+/Fe2+ system as a potential new class of anti-parasitic drugs

Cvetkovski, Aleksandar (2024) Modelling of binding affinity of siderophores with redox Fe3+/Fe2+ system as a potential new class of anti-parasitic drugs. [Project] (Unpublished)

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Abstract

A lack or ineffective treatments and vaccines for some diseases like malaria and cancer concerns and challenges public health issues nowadays to provide effective and efficiency therapy regimens toward class new classes of drugs with novel mechanisms of action [1]. In 2020, there were an estimated 241 million cases of malaria worldwide, and the estimated number of deaths stood at 627,000 [2]. Because the fight against this disease is focused on controlling the Anopheles mosquito that transmits the parasite [3] and on vaccination, many of these works have not advanced. Nevertheless, the recent approaches in chemoprevention [4] make necessary the development of new alternatives in malaria treatment. Siderophores are low-molecular-weight secondary metabolites that function as iron chelators offer a viable alternative to face these clinical problems. Under iron-deficiency conditions, they are produced by a wide variety of microbes, allowing them to increase their iron uptake. The primary function of these compounds is the environmental iron scavenging and its transport into the cytosol. Depending on their functional group, siderophores are classified into hydroxamate, catecholate, phenolate, carboxylate, and mixed types. They have achieved great importance in recent years due to their medical applications as antimicrobial, antimalarial, or anticancer drugs, vaccines, and drug-delivery agents.

Item Type:	Project
Subjects:	Medical and Health Sciences > Basic medicine Engineering and Technology > Chemical engineering Natural sciences > Chemical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Cvetkovski
Date Deposited:	25 Sep 2024 10:38
Last Modified:	25 Sep 2024 10:38
URI:	https://eprints.ugd.edu.mk/id/eprint/34713

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