Survey on repurposing of anti-parasitic drugs in babasia teratment

Cvetkovski, Aleksandar (2024) Survey on repurposing of anti-parasitic drugs in babasia teratment. In: Advancements in Structural and Functional Drug Discovery of Vector-borne Diseases, 3-5 July 2024, Oxford, UK.

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Abstract

Drug repurposing (DR)/ repositioning is an effective strategy in discovering or developing new pharmacological/therapeutic indications utilizing already approved, conventional drugs or that ones in pipeline. Though many anti-malaria drugs, such as artesunate, artemether, dihydroartemisinin, and chloroquine, lumefantrine, have been repurposed in treatment of Babesia, their efficacy against parasite infection at the selected dose has been decreased [1]. We present the review of case studies of anti-malaria drugs with potent anti-babnesia activities. Inefficiency in inhibition of early-stage of parasite development that exerts chloroquione in babesia therapy is due to lacking of hemozoin in parasite specimen Babesia comparing to Naphtoquine phosphate salt which mechanism of action has been assessed to inhibition of hemozoin bio-crystallization in the digestive vacuole at the late-satge of parasite and disruption of the membrane system. Case study on modelling of B. bovis Thrombospondin-Related
Anonymous Protein, TRAP1 and TRAP4 tertiary structure reveals proteins folded the metal-ion-dependent adhesion site (MIDAS) domain structure of Plasmodium TRAP proteins may serve as potential vaccine targets to prevent infection of bovine and ticks with B. bovis essential for controlling the spread of bovine babesiosis. [2]
Reference:
1.Ji, et al. Parasites Vectors 15, 10 (2022).
2. Masterson HE, et al., Microorganisms. 2022 Nov 2;10(11):2173.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine Engineering and Technology > Chemical engineering Natural sciences > Chemical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Cvetkovski
Date Deposited:	26 Sep 2024 10:59
Last Modified:	26 Sep 2024 10:59
URI:	https://eprints.ugd.edu.mk/id/eprint/34712

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