The influence of cation-exchange cartridge on quality of [18F]NaF radiopharmaceutical

Atanasova, Marija and Kolevska, Katerina and Cocevska, Maja and Velickovska, Maja and Jolevski, Filip and Ugrinska, Ana and Janevik-Ivanovska, Emilija (2023) The influence of cation-exchange cartridge on quality of [18F]NaF radiopharmaceutical. Macedonian pharmaceutical bulletin, 69 (Sup.1). pp. 155-156. ISSN 1857 - 8969

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Abstract

[
18F]Sodium fluoride is a positron emitting
radiopharmaceutical used for imaging of metastatic bone
disease and microcalcification (Ahuja et al., 2020). The
radioisotope fluorine-18 in form of anion [18F]F is
produced with proton irradiation of small volume oxygen 18 enriched water in targets. After the bombardment, the
irradiated enriched water, not only [18F]fluoride ion, but
also contains other radioactive and nonradioactive ions
(Köhler et al., 2013, Choi et al., 2016). According to the
European Pharmacopoeia monograph, two common
approaches are used to purify the produced fluoride-18
from target water, such us anion-exchange cartridges or
electrochemical deposition and redissolution (Ph. Eur. 10,
01/2008:2100, 2020). By identifying the most appropriate
type of SPE cartridges, this study aims to optimize the
purification process and ensure the production of highquality sodium [18F]fluoride radiopharmaceutical for
clinical use.

Item Type:	Article
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Maja Cocevska
Date Deposited:	27 Jun 2024 10:58
Last Modified:	27 Jun 2024 10:58
URI:	https://eprints.ugd.edu.mk/id/eprint/34350

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