Tripunoski, Toni and Mathe, Domokos and Balogh, Lajos and Ugrinska, Ana and Cocevska, Maja and Stojanoski, Sinisha and Bozinovska, Nikolina and Manevska, Nevena and Jankulovska, Ana-Marija and PopGjorceva, Daniela (2023) Biodistribution study of 188Re-HEDP as a radiopharmaceutical for bone pain palliation. Journal of Morphological Sciences, 6 (3).
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BIODISTRIBUTION STUDY OF 188Re-HEDP AS A RADIOPHARMACEUTICAL FOR BONE PAIN PALLIATION.pdf Download (268kB) |
Abstract
Bone seeking radiopharmaceuticals like Rhenium-188 hydroxy ethylidene diphosphonate (188Re-HEDP)
are used for palliative treatment of bone metastases, and as target radionuclide therapy in patients with inoperable
osteosarcoma in addition to the external radiation therapy.
In this study we evaluated the preparation, quality control and biodistribution of 188Re-HEDP in mice to
determine the in vivo affinity to the target bone tissue and to the other non-target tissues and organs. 188Re-HEDP
was prepared with radiochemical purity of 98.87%.
The biodistribution data showed high uptake and durability in the skeletal tissues without significant uptake
in other tissues and organs. In conclusion, whit chosen 188Re-HEDP kit formulation and the prescribed conditions
in our study we obtained a radiopharmaceutical with promising therapeutic efficiency in palliative treatment of
primary bone tumors as well as secondary osseous metastatic lesions.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Maja Cocevska |
| Date Deposited: | 27 Jun 2024 10:49 |
| Last Modified: | 27 Jun 2024 10:49 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/34342 |
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