Higher COVID-19 Pneumonia Risk Associated With Anti-IFN-α Than With Anti-IFN-ω Auto-Abs in Children

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and Uddin, Mohammed J. and van de Beek, Diederik and Vinh, Donald C. and von Bernuth, Horst and Wauters, Joost and Zatz, Mayana and Zawadzki, Pawel and Zhang, Qian and Zhang, Shen-Ying and Peterson, Pärt and Pujol, Aurora and Lévy, Romain and Quartier, Pierre and Vinh, Donald C. and Boisson, Bertrand and Béziat, Vivien and Zhang, Shen-Ying and Borghesi, Alessandro and Pession, Andrea and Andreakos, Evangelos and Marr, Nico and Mentis, Alexios-Fotios A. and Mogensen, Trine H. and Rodríguez-Gallego, Carlos and Soler-Palacin, Pere and Colobran, Roger and Tillmann, Vallo and Neven, Bénédicte and Trouillet-Assant, Sophie and Brodin, Petter and Abel, Laurent and Jouanguy, Emmanuelle and Zhang, Qian and Martinón-Torres, Federico and Salas, Antonio and Gómez-Carballa, Alberto and Gonzalez-Granado, Luis I. and Kisand, Kai and Okada, Satoshi and Puel, Anne and Cobat, Aurélie and Casanova, Jean-Laurent (2024) Higher COVID-19 Pneumonia Risk Associated With Anti-IFN-α Than With Anti-IFN-ω Auto-Abs in Children. Journal of Experimental Medicine, 221 (2). ISSN 0022-1007

Text Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children - PMC.pdf - Published Version Download (6MB)

Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.

Item Type:	Article
Impact Factor Value:	15.3
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Sotirija Duvlis
Date Deposited:	23 May 2024 08:30
Last Modified:	23 Aug 2024 10:46
URI:	https://eprints.ugd.edu.mk/id/eprint/34029

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