Biodegradation and drug release studies of BSA loaded gelatin microspheres

Mladenovska, Kristina and Kumbaradzi, Emilija Fredro and Dodov, Glavas Marija and Makraduli, Liljana and Goracinova, Katerina (2002) Biodegradation and drug release studies of BSA loaded gelatin microspheres. International journal of pharmaceutics, 242 (1-2). pp. 247-249.

Text Biodegradation and drug release studies of BSA loaded.pdf Download (72kB)

Abstract

Certain variations in the process parameters (emulsification time, surfactant concentration) were performed in order to prepare BSA-loaded gelatin microspheres with high loading efficacy and particle size ranging from 1 to 10 μm using a procedure originally employed by Tabata and Ikada. The mathematical modelling of drug release in the presence of collagenase showed a biphasic release pattern, where the rate constant for the initial time release confirmed the influence of the particle size and/or enzymatic degradation rate on drug release rate.
© 2002 Elsevier Science B.V. All rights reserved

Item Type:	Article
Impact Factor Value:	5.8
Subjects:	Engineering and Technology > Other engineering and technologies Medical and Health Sciences > Other medical sciences Natural sciences > Other natural sciences
Divisions:	Faculty of Medical Science
Depositing User:	Liljana Makraduli
Date Deposited:	29 Mar 2024 12:09
Last Modified:	29 Mar 2024 12:09
URI:	https://eprints.ugd.edu.mk/id/eprint/33949

Actions (login required)

View Item