Factorial design analysis and optimisation of alginate—Ca-chitosan microspheres

Makraduli, Liljana and Crcarevska, Maja Simonoska and Geskovski, Nikola and Dodov, Marija Glavas and Goracinova, Katerina (2013) Factorial design analysis and optimisation of alginate—Ca-chitosan microspheres. Journal of Mmicroencapsulation, 30 (1). pp. 81-92. ISSN 0265-2048 print/ 1464-5246 online

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Abstract

The purpose of this study was to apply factorial design in order to determine the influence of the formulation factors and their interactions on several responses such as particle size, dissolution behaviour at pH 1.2 and pH 7.4 as well as production yield, during the development of budesonide loaded, chitosan coated Ca–alginate microparticles (MPs) intended for treatment of inflammatory diseases in the gastrointestinal tract. Produced drug-loaded MPs were spherical in shape, had smooth surfaces with low porosity and size range between 5 and 11 μm. Production yield for the formulations from the design varied from 19% to 50%.
Optimisation was performed using central composite design setting the targets: particle size at 5.5 μm,
maximised yield, suppressed dissolution at pH 1.2 and sustained release at pH 7.4. The optimised batches
were identified with a combined desirability value of 0.967.

Item Type:	Article
Impact Factor Value:	2.29
Subjects:	Engineering and Technology > Other engineering and technologies Medical and Health Sciences > Other medical sciences Natural sciences > Other natural sciences
Divisions:	Faculty of Medical Science
Depositing User:	Liljana Makraduli
Date Deposited:	29 Mar 2024 09:33
Last Modified:	29 Mar 2024 09:33
URI:	https://eprints.ugd.edu.mk/id/eprint/33893

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