Metabolic syndrome (MetS) as one of the major comorbidities of chronic obstructive pulmonary disease (COPD)

Buklioska Ilievska, Daniela and Mickovski, Ivana and Baloski, Marjan and Bushev, Jane and Minov, Jordan and Gigovska-Dimova, Irena and Eftimovska-Otovikj, Natasha and Miloshevska, Radmila (2023) Metabolic syndrome (MetS) as one of the major comorbidities of chronic obstructive pulmonary disease (COPD). Respiratio medical journal, 13 (1-2). pp. 45-56.

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Abstract

Aim: We aimed to investigate the association between COPD and MetS, the relation to the severity of
airflow limitation.
Methods: This is a cross-sectional study including 220 patients with initially diagnosed COPD (IG),
aged 40 to 75 years and 58 non-COPD subjects matched by age, smoking status, body mass index, as
controls (CG). All study participants underwent anthropometric measurements, fasting blood sugar
(FBS), lipid profile, pulmonary evaluation (dyspnea severity assessment, baseline and postbronchodilator spirometry, gas analyses, chest X-ray).
Results: Results presented statistically significant difference in presence of MetS in COPD patients
compared to controls (32.27% vs 10.34%; P=0.0009). According to the GOLD classification, the
frequencies of MetS in COPD patients were categorized in stages I, II, III, IV (17.54%, 37.10%, 34.62%,
40.82%, respectively). The proportion of patients with increased glycemic values was: a) GOLD1 - 18
(31.58%); b) GOLD 2 - 32 (51.61%); c) GOLD3 - 29 (55.77%); and d) GOLD4 - 31 (63.27%). There
was no significant difference between IG and CG patients regarding HDL level. According to arterial
hypertension the highest proportion was observed in GOLD3 - 22 (42.31%) followed by GOLD4 - 20
(40.82%), and GOLD3 - 22 (35.48 %), smallest in GOLD1 - 17 (29.82%).
Conclusion: We found higher prevalence of MetS in patients with COPD even in early COPD stages
compared to non-COPD. Our findings suggest an urgent need to develop comprehensive strategies for
prevention, screening and start of treatment in early stage.
Key words: COPD, metabolic syndrome, dyslipidemia, obesity.

Item Type:	Article
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Ivana Mickovski
Date Deposited:	26 Feb 2024 11:22
Last Modified:	26 Feb 2024 11:22
URI:	https://eprints.ugd.edu.mk/id/eprint/33702

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