Mandak, Zehrija and Velkoska Nakova, Valentina and Zdravkovska, Milka (2022) Analysis of cardiospecific enzymes in patients with coronary artery disease. Knowledge – International Journal, 51 (4). pp. 615-619.
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Abstract
Abstract: The primary aim was to compare the specific and nonspecific cardiac enzymes in patients presented with
acute coronary syndrome and those with selective coronary angiography. The second aim was to evaluate the
relationship between different outcomes and levels of cardiac enzymes.
Retrospectively were analyzed 270 patients, 94 cases with acute coronary syndrome and 176 patients with selective
coronary angiography (SCA). In all patients, myocardial serum enzyme levels (troponin I, creatinine phosphokinase
(CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH)), and inflammatory markers (C-reactive
protein and white blood cells) were measured. All patients were submitted to coronary angiography and outcomes
were analyzed.
From 94 patients with ACSy, 56 (59.6%) patients received at least one coronary artery stent, 27 (28.7%) were
referred to cardiac surgery for aorta-coronary bypass, and 11 (11.7%) died. From 176 patients with SCA, 46 (26.1%)
received at least one coronary artery stent, 24 (13.6%) patients were referred for aorta-coronary bypass, 106 (60.2%)
patients were without significant coronary plaques and were discharged with drug treatment, and no one died.
Patients with ACSy had significantly higher levels of troponin, AST, CK, and LDH compared to patients in SCA
group. Mean values of CK-MB, CRP and peripheral white blood counts were not significantly different in patients
with ACSy than in patients with SCA.
Statistically significant positive correlation between the ACSy event and troponin, AST, CK, and CKMB values
were found. The correlation coefficient was strong for troponin and weak in other enzymes.
Using the general linear model-univariate procedure, only the age have statistically significant effect on coronary
angiographic outcome.
Our findings suggest that serum levels of specific myocardial enzymes are elevated in patients presented with ASCy
and can be used to identify patients for urgent coronary angiography. According to our results, the levels of the
inflammatory markers can’t be used for prognosis stratifications.
The advanced age have the highest impact on the coronary angiography outcomes in the group of patients which
fulfill criteria for coronary angiography. Number of other cardiac markers (myoglobin, hyperuricemia and
interleukins) were not analyzed in this study.
Keywords: acute coronary syndrome, cardiac enzymes, troponin, coronary angiography
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Valentina Velkovska |
| Date Deposited: | 01 Feb 2024 12:49 |
| Last Modified: | 01 Feb 2024 12:49 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/33367 |
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