Comparison in lipid parameters before and after L-thyroxine treatment in subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies

Velkoska Nakova, Valentina and Krstevska, Brankica and Cheshlaroska, Markushoska Katerina and Jovanovska, Mishevska Sasha and Milenkovic, Tatjana (2022) Comparison in lipid parameters before and after L-thyroxine treatment in subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies. In: European Congress of Endocrinology 2022.

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Abstract

Objective: Subclinical hypothyroidism (ScH) is a common condition and may be associated with dyslipidemia. We investigated the effect of levothyroxine therapy (L-T4) on lipid parameters in patients with a mild form of subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies (anti-TPO antibodies).
Material and methods: Fifty-seven patients with newly diagnosed ScH (TSH levels between upper reference value and 10 mIU/l with normal FT4 and FT3 values) with indications for L-T4 therapy were included in the study. Lipid parameters and presence of anti-TPO antibodies were evaluated at the moment of diagnosis and after 6 months euthyroid stage.
Results: Average value of TSH was 8.1 G1.9 mIU/l. Thyroid substitution therapy significantly decreased total cholesterol and LDL-C, and increased HDL-C (5.6G
0.9 vs. 5.3G1.1; 3.4G1.0 vs. 3.2G1.1; 1.5G0.5 vs. 1.6G0.5 mmol/l, P!0.05 respectively). Statistically significant decrease in total cholesterol, total cholesterol/HDL-C, and, LDL-C/HDL-C were observed in patients with positive
anti-TPO antibodies after 6 months euthyroid state (5.5G1.1 vs 5.3G 0.9 mmol/l; 3.9G1.5 vs. 3.5G1.0; 2.5G1.2 vs. 2.2G0.8, P!0.5 respectively). There was not statistically significant differences in lipid profile in patients with negative anti-TPO antibodies before and after L-T4 treatment.
Conclusion: The effect of the thyroid substitution therapy on lipid parameters was more pronounced in patients with mild ScH and positive thyroid antibodies. Patients with mild ScH and positive anti-TPO antibodies may benefit of L-T4 treatment
even in the lower TSH values.
Key words: subclinical hypothyroidism, thyroid peroxidase antibodies, levothyroxine therapy

Item Type:	Conference or Workshop Item (Speech)
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Valentina Velkovska
Date Deposited:	01 Feb 2024 12:52
Last Modified:	01 Feb 2024 12:52
URI:	https://eprints.ugd.edu.mk/id/eprint/33365

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