Velkoska Nakova, Valentina and Krstevska, Brankica and Cheshlaroska, Markushoska Katerina and Jovanovska, Mishevska Sasha and Milenkovic, Tatjana (2022) Comparison in lipid parameters before and after L-thyroxine treatment in subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies. In: European Congress of Endocrinology 2022.
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Abstract
Objective: Subclinical hypothyroidism (ScH) is a common condition and may be associated with dyslipidemia. We investigated the effect of levothyroxine therapy (L-T4) on lipid parameters in patients with a mild form of subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies (anti-TPO antibodies).
Material and methods: Fifty-seven patients with newly diagnosed ScH (TSH levels between upper reference value and 10 mIU/l with normal FT4 and FT3 values) with indications for L-T4 therapy were included in the study. Lipid parameters and presence of anti-TPO antibodies were evaluated at the moment of diagnosis and after 6 months euthyroid stage.
Results: Average value of TSH was 8.1 G1.9 mIU/l. Thyroid substitution therapy significantly decreased total cholesterol and LDL-C, and increased HDL-C (5.6G
0.9 vs. 5.3G1.1; 3.4G1.0 vs. 3.2G1.1; 1.5G0.5 vs. 1.6G0.5 mmol/l, P!0.05 respectively). Statistically significant decrease in total cholesterol, total cholesterol/HDL-C, and, LDL-C/HDL-C were observed in patients with positive
anti-TPO antibodies after 6 months euthyroid state (5.5G1.1 vs 5.3G 0.9 mmol/l; 3.9G1.5 vs. 3.5G1.0; 2.5G1.2 vs. 2.2G0.8, P!0.5 respectively). There was not statistically significant differences in lipid profile in patients with negative anti-TPO antibodies before and after L-T4 treatment.
Conclusion: The effect of the thyroid substitution therapy on lipid parameters was more pronounced in patients with mild ScH and positive thyroid antibodies. Patients with mild ScH and positive anti-TPO antibodies may benefit of L-T4 treatment
even in the lower TSH values.
Key words: subclinical hypothyroidism, thyroid peroxidase antibodies, levothyroxine therapy
Item Type: | Conference or Workshop Item (Speech) |
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Subjects: | Medical and Health Sciences > Clinical medicine |
Divisions: | Faculty of Medical Science |
Depositing User: | Valentina Velkovska |
Date Deposited: | 01 Feb 2024 12:52 |
Last Modified: | 01 Feb 2024 12:52 |
URI: | https://eprints.ugd.edu.mk/id/eprint/33365 |
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