Buklioska Ilievska, Daniela and Minov, Jordan (2024) Anemia as a Comorbidity in COPD Patients. In: XI International Workshop on Lung Health, 18-20 Jan 2024, Seville, Spain.
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Abstract
Introduction: Anemia is common in patients with chronic diseases and associated with impaired long-term
survival and quality of life. The prevalence of comorbid anemia in patients with COPD ranges from 7.5% to
34%, depending upon the populations selected and diagnostic tools employed to determine the level of
hemoglobin. The true prevalence of anemia in patients with COPD, its impact on quality of life, healthcare
utilization, and mortality in patients with COPD is unknown. The prevalence of coexisting anemia in COPD
is highly variable and depends on the severity of the lung disease, the presence of other comorbidities, and
other factors such as socioeconomic status and race.
Material and method: The design is a cross-sectional study, including 220 patients with stable COPD as investigated group (IG), aged 40-75 years and 58 non-COPD subjects, matched by gender, age, body mass index (BMI), smoking-status, as control group (CG). All study subjects underwent pulmonary evaluation (dyspnea
severity assessment, baseline and post-bronchodilator spirometry, gas analyses, chest X-ray, 6-minute walk
distance, modified Medical Research Council dyspnea questionnaire, St. George’s Respiratory Questionnaire),
and laboratory analyses (blood count, sedimentation rate, c-reactive protein (CRP), routine biochemistry).
Patients were classified as anemic based on hemoglobin (Hgb) levels (Hgb<12/13 g/dl, female patients/male
patients, according to The World Health Organization). Patients with known causes for anemia were excluded.
Results presented statistically significant difference between presence of normocytic anemia in IG 13.6%
(n=30) vs. CG 3% (n=3) (p<0.05). There was a significant linear positive correlation between anemia and
GOLD stage (R=0.174; p<0.05). With decrease of FEV1(GOLD1→GOLD4), the frequency of anemia increased,
significantly. According to gender anemia was more frequent in male 9% (n=20), vs. female 4.5% (n=10)
(p<0.05). Anemia was associated with higher levels of serum C-reactive protein in COPD patients with anemia,
10.5mg/L, vs COPD patients without anemia 2.3mg/L (p<0.05). Anemic participants were older with worse airflow obstruction and they had a higher prevalence of cardiac and metabolic comorbidities. Anemia was strongly associated with 6-minute walk distance (β, −62.34; 95% confidence interval [CI], −84.12 to −36.63),
St. George’s Respiratory Questionnaire (β, 3.82; 95% CI, 1.06–6.62) and modified Medical Research Council
dyspnea questionnaire (β, 0.31; 95% CI, 0.12–0.45). There was a significant linear positive correlation between anemia and BMI (p=0.012)
Conclusion: Comorbid anemia in patients with COPD was associated with greater healthcare resource utilization, impaired quality of life, older age, and male gender. Moreover, anemia in patients with COPD is an
independent prognostic predictor of premature mortality and a greater likelihood of hospitalization. Based
on the findings from the existing literature, more work is necessary to establish the true prevalence of anemia in COPD. More prospective clinical studies are needed to improve the management of COPD patients with comorbid anemia.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Additional Information: | The fil rouge of the XI International Workshop on Lung Health has been defined: “New Scenarios” is the main theme which embraces sessions, lectures, and symposia. During the 3 Workshop days major and outbreaking topics of Respiratory Medicine: from Asthma and COPD to Respiratory Infections, reaching also the Interstitial and Rare Diseases, focusing on the most recent updates and perspectives, in terms of clinical advances and research outcomes. |
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Daniela Buklioska Ilievska |
| Date Deposited: | 01 Feb 2024 08:12 |
| Last Modified: | 01 Feb 2024 08:12 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/33326 |
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