Design of feasibility study for the establishment of production of zirconium-89 radioisotope and implementation of 89Zr-radiopharmaceuticals in clinical practice in the Republic of North Macedonia

Kolevska, Katerina and Atanasova, Marija and Cocevska, Maja and Velickovska, Maja and Jolevski, Filip and Tripunoski, Toni and Memeti, Shaban and Ugrinska, Ana and Angelovska, Bistra (2023) Design of feasibility study for the establishment of production of zirconium-89 radioisotope and implementation of 89Zr-radiopharmaceuticals in clinical practice in the Republic of North Macedonia. Archives of Public Health (Arch Pub Health), 15 (1).

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Abstract

The radiopharmaceuticals based on zirconium-89 (89Zr) radiometal, in the last decade, have increased application in both preclinical and clinical studies. The most frequently used 89Zr-radiopharmaceutical is 89Zr-trastuzumab used in the management of patients with breast cancer. Breast cancer is the most common cancer among women in North Macedonia and the most common cause of death from malignant neoplasms in this population, therefore the introduction of new nuclear medicine procedures in these patients might improve the management of this disease. However, the introduction of radioisotope and radiopharmaceutical production requires significant investments, both manpower and financial.
In order to assess the feasibility of establishing the production of zirconium-89 radioisotope and 89Zr-radiopharmaceuticals at the University Institute of Positron Emission Tomography (UI PET), a feasibility study is designed.
The purpose of this work is to present the design conceptualization of a feasibility study for the establishment of production of zirconium-89 radioisotope and implementation of 89Zr-radiopharmaceuticals in clinical practice in the Republic of North Macedonia and to present the initial results from the first phases of the study. This feasibility study is designed to include preliminary analysis, market research, technical feasibility analysis, economic analysis, review and analysis of all data and feasibility conclusion.
The evaluation of the data from the analyses conducted in all study phases is needed to identify the favourable and unfavourable factors and circumstances in order to make a final assessment of the feasibility of establishing the zirconium-89 radioisotope and 89Zr-radiopharmaceuticals production and implementation of 89Zr-trastuzumab use in nuclear medicine practice.
Keywords: feasibility study, zirconium-89 radioisotope, 89Zr-radiopharmaceuticals, production, 89Zr-trastuzumab

Item Type:	Article
Subjects:	Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Katerina Kolevska
Date Deposited:	11 Dec 2023 10:54
Last Modified:	11 Dec 2023 10:54
URI:	https://eprints.ugd.edu.mk/id/eprint/32815

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