Correlation between the presence of an odontogenic radicular cyst and the human immune response

Stojanova, Irena and Dimitrovski, Oliver and Veleska-Stefkovska, Daniela and Markovska Arsovska, Mirjana and Spirov, Vancho and Bajrami, Muhamet (2022) Correlation between the presence of an odontogenic radicular cyst and the human immune response. In: 9th Congress of Macedonian dental society with international participation "Challenging new era in dentistry: burden and opportunities", 15-18 Sept 2022, Ohrid, Republic of North Macedonia.

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Abstract

Aim: The aim of this study was to determine the presence of T and B lymphocytes cells in the inflammatory infiltrate and the impact of the cystic lesion on the systemic immune response by verifying the changes in the immune system by applying immunohistochemical method in a patient with residual cyst in the lower jaw. and one month after surgery.
Material and method: Case Report: A 60-year-old woman with a residual cyst in her lower jaw came to the Oral Surgery Clinic. Immunoassay of blood was performed to determine the values of immunoglobulins IgA, IgG and Ig M before surgery, cyst enucleation in toto- Partch II, pathohistological and immunohistochemical analysis of CD3, CD4, CD8, CD20 and CD68 markers. Immunological blood tests were performed one month after surgery.
Results: Pathohistological and immunohistochemical analysis confirmed the diagnosis of radicular (residual) cyst in the mandible with the presence of multilayered squamous epithelium beneath which is an inflammatory infiltrate with granulation tissue and deposited cholesterol crystals with predominant macrophages and histiocytes. Levels of serum immunoglobulins IgA, Ig G and IgM levels were reduced after surgery.
Conclusion: The use of pathohistological and immunohistochemical analyses proves the presence of cellular and humoral immune responses and their role in the etiopathogenesis and development of cysts, while immunoassays confirm the presence of human immunoglobulin this suggests the importance of early detection and therapeutic approach to radicular cysts.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Vanco Spirov
Date Deposited:	25 Jan 2024 13:24
Last Modified:	25 Jan 2024 13:24
URI:	https://eprints.ugd.edu.mk/id/eprint/32800

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