miRNA as a diagnostic marker for cell differentiation and proliferation and altered gene expression

Arsovska, Natalija and Velickova, Nevenka (2023) miRNA as a diagnostic marker for cell differentiation and proliferation and altered gene expression. Knowledge – International Journal, 56 (3). pp. 279-283. ISSN 2545-4439 / 1857-923X (Printed)

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Abstract

Introduction: Micro RNAs (miRNA) are short non-coding RNA molecules that have an important regulatory role in mRNA translation. More than 1000 different miRNA molecules have been detected in humans, which are necessary for many cellular processes. Different expressions of miRNAs are specific to individual tissues and are associated with a variety of pathological diseases. These properties make miRNA a potential and non-invasive diagnostic research biomarker. Aims of the study: To emphasis the improvement and needs of expression analysis of miRNA as a potential non-invasive diagnostic and prognostic biomarkers. Material and methods: In this review article is explain all the procedure, the advantages and disadvantages of the most common miRNA detection methods, and highlights the lack of standardization in all steps of miRNA detection. Results and discussions: We compare and explain main findings of different studies about the involvement of miRNAs in diseases that affect a large part of the human population. Conclusions: As a consequence, and previously study’s findings human miRNAs are likely to be very useful as biomarkers, especially for future cancer diagnostics, and are rapidly emerging as attractive targets for disease intervention.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine
Divisions:	Faculty of Medical Science
Depositing User:	Nevenka Velickova
Date Deposited:	28 Sep 2023 09:05
Last Modified:	28 Sep 2023 09:05
URI:	https://eprints.ugd.edu.mk/id/eprint/32269

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