Influence of beta-cyclodextrin on the phase transition in carbamazepine polymorphs

Cvetkovski, Aleksandar and Drakalska, Elena (2023) Influence of beta-cyclodextrin on the phase transition in carbamazepine polymorphs. Macedonian pharmaceutical bulletin, 69 (Suppl 1) 189 - 190 (2023). ISSN DOI: 10.33320/maced.pharm.bull.2023.69.03.093

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Abstract

Results confirm that phase transition of CBZ
polymorphs, anhydrous form III and I leading to less water
soluble CBZ pseudopolymoprph, dihydrate form during
the kneading and formation of IC with BCD occur
simultaneously. Less water soluble and stable at ambient
temperature CBZ III, thus less favorable for transition in
CBZ dihydrate, in grinded binary sample with BCD exerts
higher water solubility due to formation of IC. BCD in high
extent retains inhibition of phase transition of CBZ III to
CBZ I during the DCS heating cycle. ICs as immediate
release drug delivery systems offer further opportunities
for design modified release formulations that may include
IC in combination with a polymeric matrix formation
compound for additional control of both the drug release
profile and drug phase transition.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Engineering and Technology > Chemical engineering Natural sciences > Chemical sciences Engineering and Technology > Materials engineering Engineering and Technology > Nano-technology
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Cvetkovski
Date Deposited:	28 Sep 2023 08:55
Last Modified:	28 Sep 2023 08:55
URI:	https://eprints.ugd.edu.mk/id/eprint/32259

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