Influence of mechanochemical processing to phase transition of carbamazepine polymorphs and formation of Inclusion Complex with cyclodextrin

Cvetkovski, Aleksandar and Drakalska, Elena (2023) Influence of mechanochemical processing to phase transition of carbamazepine polymorphs and formation of Inclusion Complex with cyclodextrin. In: Mechanochemistry in Europe: Challenges, Outcomes, Syntheses, Targets, 22-23 June 2023, Cagliari, Italy.

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Abstract

Upon grinding both the reactivity and the reaction selectivity are usually improved resulting in a reduced reaction time and a decreased number of purification steps.
Role of Mechanochemistry in Inclusion Complexes (ICs) formation
The solid-state reactivity is much more linked to diffusion phenomena in the crystalline parts of the material than to the increase in the surface area of the CD particles resulting from grinding.
supramolecular effects (diffusion through channels)
the reaction rate is not directly proportional to the aggregate total active area of contact between the reactants
mechanically assisted reaction proceeds with higher selectivity with change of pH value
The quantification of the grinding contribution in the reactivity was lacking at this stage (it was not clear whether the increase in reactivity was only a consequence of the formation of inclusion complexes, or whether the grinding process was also involved).
Water molecule in cavity loses out 2 H-bonds, higher degree of freedom; enthalpically driven hydrophobic inclusion

Outline of the lecture:

Molecular & Crystal Structures of Cyclodextrins (CDs)
The Crystal Structure of drug model Carbamazepin (CBZ) polymorphs III & I
CD Inclusion Complexes (ICs)
Role of Mechanochemistry in IC formation
Experimental Design for IC CBZ polymorphs / BCD
Results

Item Type:	Conference or Workshop Item (Lecture)
Subjects:	Medical and Health Sciences > Basic medicine Engineering and Technology > Chemical engineering Natural sciences > Chemical sciences Engineering and Technology > Materials engineering Engineering and Technology > Nano-technology
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Cvetkovski
Date Deposited:	28 Sep 2023 08:53
Last Modified:	28 Sep 2023 08:53
URI:	https://eprints.ugd.edu.mk/id/eprint/32253

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