The SARS-CoV-2 Delta (B.1.617.2) variant with spike N501Y mutation in the shadow of Omicron emergence

Salimović-Bešić, Irma and Dedeić-Ljubović, Amela and Zahirović, Edina and Hasanović, Medina and Šehić, Merima and Vukovikj, Maja and Boshevska, Golubinka and Vegar-Zubović, Sandra and Mehmedika-Suljić, Enra and Izetbegović, Sebija (2022) The SARS-CoV-2 Delta (B.1.617.2) variant with spike N501Y mutation in the shadow of Omicron emergence. Heliyon, 8 (12). ISSN 2405-8440

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Abstract

Circulation of the Omicron variant with the reemergence of the N501Y mutation along with many others in the
spike protein has once again stirred the academic community. Interestingly, tracing the genetic diversity of SARSCoV-
2 shed light on a less frequent N501Y þ Delta variant which has been in the global circulation for some time
before the Omicron appearance. This paper aims to present the molecular characteristics of the SARS-CoV-2
Spike_N501Y þ Delta variant detected in Bosnia and Herzegovina. The study was conducted during November
and December 2021. All patients were tested using real-time RT-PCR for detection of SARS-CoV-2. A representative
number of SARS-CoV-2 positive samples was pre-screened using VirSNiP SARS-CoV-2 Spike N501Y kit. The
characterization of the viruses was carried out with Illumina RNA Prep with enrichment and the Respiratory Virus
Oligo Panel kit. Among the analyzed sequences, we found two isolates of the Delta variant that differ from their
most related clade- GK AY.4.3 in additional mutations N501Y and L54F. In this study, we described the presence
of a rare form of Delta variant with Spike_N501Y mutation in the shadow of the Omicron emergence. Despite the
set of mutations in the Spike protein, this form of Delta variant does not indicate the large-scale consequences for
the general population. Further functional studies of this form could provide more information about its antigenicity
and infectivity.

Item Type:	Article
Impact Factor Value:	3.776
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Golubinka Bosevska
Date Deposited:	20 Sep 2023 11:15
Last Modified:	20 Sep 2023 11:15
URI:	https://eprints.ugd.edu.mk/id/eprint/32203

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