medication-overuse headache (MOH)

Yzeiri Havziu, Drita and Gjorgjeska, Biljana and Bexheti, Dorentina and Haxhiu Zaimi, Arlinda and Shabani, Arijeta and Dauti, Merita and Alili Idrizi, Edita and Gjylaj, Alija and Ballashi, Lulzime and Ahmeti Lika, Sihana (2023) medication-overuse headache (MOH). In: International Congress on Natural, Health Sciences and Technology, 15-17 May 2023, Tetovo.

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Abstract

Migraine is a common headache disorder that causes significant disabilities. Headache developed or significantly worsened during medication overuse (for simple analgesics and combination acute medications, intake must be 15 days or more per month for triptans, ergotamines, opioids, and combination analgesics; 10 days per month sufficient to get a diagnosis of Medication-overuse headache-MOH). A recent epidemiologic study on drug-induced disorders demonstrated that excessive drug use can lead to nephrotoxicity. Microalbuminuria was common in patients under the influence of nephrotoxic drugs. Subclinical renal damage cannot be identified by routine tests (serum creatinine), and microalbuminuria is a more sensitive indicator of renal dysfunction. The aim is to confirm the sensitivity of certain biomarkers when comparing patients treated with NSAIDs in combination with other drugs (analgesics, triptans and antidepressants) with patients treated with monotherapy by NSAIDs Besides conventional markers of renal functioning (serum/urine creatinine determined by Jaffe methods), enzymatic assay for urea serum and Jon selective electrode (ISE) are used fordetermination of electrolite in serum. Imunoturbodimetric assay for determination of urinary albumin, microalbuminuria and β2-
microglobulin will be used. In the case of combination therapy (analgesics, triptans and antidepressants) a significant effect on the increase of microalbuminuria has been demonstrated.
Keywords: Medication-overuse headache, Nephrotoxicity, Microalbuminuria.

Item Type:	Conference or Workshop Item (Speech)
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Biljana Gorgeska
Date Deposited:	14 Jun 2023 08:50
Last Modified:	14 Jun 2023 08:50
URI:	https://eprints.ugd.edu.mk/id/eprint/31898

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