Preparation and evaluation of gel emulsion with meloxicam

Drakalska, Elena and Angelovska, Bistra and Dimova, Dobrinka and Makraduli, Liljana (2023) Preparation and evaluation of gel emulsion with meloxicam. In: 8th Congress of Pharmacy with International Participation, 27-30 April, 2023, Hotel Rila, Borovets, Bulgaria.

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Abstract

(I) Aim of the study
Meloxicam is one of the most potent non-steroidal anti-inflammatory drugs, generally indicated for treatment of rheumatoid arthritis, osteoarthritis and juvenile arthritis and commercially available in form of tablets and suspension with recommended daily dose 7.5-15 mg. Unfortunately, long-term administration usually in higher doses is associated with increased risk of gastro-intestinal bleeding, cardiac arrest and stroke. An alternative approach to overcome these limitations is design of topical forms. The aim of this study is characterization and evaluation of gel-emulsion with meloxicam.
(II) Materials and methods
The present study is focused on elaboration of gel-emulsion composed of TEGO Carbomer 134 as gelling agent, propylene glycol as solubilizer, Tween 60 and Span 60 as emulsifiers, liquid paraffin as vehicle of oil phase from gel-emulsion, triethanolamine as pH adjuster and menthol as rubefacient whereby meloxicam is incorporated as free drug in oil phase. Prepared gel-emulsion was characterized for content, pH, spreadability, viscosity and microbial examination was performed.
(III) Results and discussion
Obtained results showed homogenous, easy spreadable, translucent gel-emulsion. Upon visual examination, no phase separation was observed. The percentage of drug content in gel-emulsion was 103%, spreadability was 9.2 cm and viscosity was 25 500 CP. Measured pH was 6.45 which is suitable for dermal application without risk of irritation. Additionally, absence of specific microorganisms tested was determined.
(IV) Conclusion
Even though gel-emulsion was stable and pharmacologically active for topical application, however, further investigations are needed in order to determine safety and security of developed formulation.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Elena Drakalska
Date Deposited:	02 May 2023 08:27
Last Modified:	29 Mar 2024 12:10
URI:	https://eprints.ugd.edu.mk/id/eprint/31689

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