Covid-19 pneumonia associated with rhabdomyolysis in patient with previous chronic therapy with statin: coincidence or realted conditions?

Janeku Kartalova, Marija and Cvetanovska, Marija and Stevanovic, Milena and Demiri, Ilir and Bogoeva Tasevska, Suncica and Cvetanovski, Vlatko (2021) Covid-19 pneumonia associated with rhabdomyolysis in patient with previous chronic therapy with statin: coincidence or realted conditions? Journal of morphological sciences, 4 (1). pp. 6-12. ISSN 2545-4706

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus which causes coronavirus disease 2019 (COVID-19). It was first identified amid an outbreakof respiratory illness cases in Wuhan, China. The manifestationof COVID-19 rangesfrom asymptomatic or mild symptoms to severe illness or death.The most serious complication of COVID-19 is a type of pneumonia thathas been namedCOVID-19 pneumonia presents as an atypical pneumonia, with diffuse bilateral lung involvement. Severe cases present with acute lung injury, and acute respiratory distress syndrome.Rhabdomyolisis can be an initial manifestation of COVID-19, but it is also a life-threatening disorder. Rhabdomyolysis is the breakdown of skeletal muscle by releasing itscellular content into the systemic circulation.A 73-year-old man was admitted to our hospital with bilateral pneumonia, musclepain, and worsening symptoms. His oxygen saturation got low, so we started treatment with oxygen inhalation by a high-flow mask. On the 14th hospital day,the muscle enzymes started to increase. After adequate treatment the patient was discharged on hospital day 28.Patientswith COVID-19 pneumonia can develop rhabdomyolysis because of SARS CoV-2 infection.There is a risk of developing rhabdomyolysis after using drugsfor treatment of COVID-19. Our patient was on previous chronic therapy with statins,but with normal liver and muscle enzymes. During his hospitalization and deteriorationof his clinical condition the enzymes increased and rhabdomyolysisdeveloped.Our findings indicate that rapid clinical recognition and positive hydration treatmentof COVID-19–associated rhabdomyolysis can reduce the risk of serious complications.
Keywords:SARS-CoV-2, COVID-19, COVID-19 pneumonia, rhabdomyolysis, chronic statin therapy

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Vlatko Cvetanovski
Date Deposited: 10 Mar 2023 08:56
Last Modified: 10 Mar 2023 08:56
URI: https://eprints.ugd.edu.mk/id/eprint/31523

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