Stefova, Marina and Ivanova, Violeta and Muratovska, Ilijana (2005) Identification and Quantification of Bis-GMA and Teg-DMA Released from Dental Materials by HPLC. Journal of Liquid Chromatography & Related Technologies, 28. pp. 289-295.
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Abstract
Most of the composites and sealants used in dentistry are based on bisphenol
A diglycidylether methacrylate (Bis-GMA) and triethylenglycol dimethacrylate
(Teg-DMA). Reports revealed that in situ polymerization is not complete and that
free monomers can be detected by different analytical methods. We studied residual
Bis-GMA and Teg-DMA after in vitro polymerization by high performance liquid
chromatography (HPLC) after 24 hr, 7, and 14 days. For quantitative analysis, an
RP column (250 � 4.6 mm; 5mm) as stationary phase and isocratic elution with
CH3CN:H2O (60 : 40) was used. A calibration curve was constructed using standard
solutions of Bis-GMA and Teg-DMA in the concentration range from 1 � 1023 to
5 � 1025 mol/L. The limits of detection (LOD) and quantification (LOQ) for both
analytes were determined (for Bis-GMA: 0.0076 and 0.0229 mmol/L; and for Teg-
DMA: 0.0123 and 0.0373 mmol/L, respectively). The accuracy of the method was
confirmed by standard additions. The HPLC analysis of residual components
revealed that Bis-GMA was released from commercial samples in the highest concentration
after 14 days. Teg-DMA was detected only in one of all analyzed dental
materials.
| Item Type: | Article |
|---|---|
| Subjects: | Natural sciences > Chemical sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Agriculture |
| Depositing User: | Violeta Ivanova Petropulos |
| Date Deposited: | 05 Nov 2012 08:21 |
| Last Modified: | 28 Oct 2013 12:45 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/315 |
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