The predictive role of selective laboratory parameters for the occurance of “unwanted events” in adults with laparoscopic appendectomy

Milev, Ilija and Velikj Stefanovska, Vesna and Mitevski, Aleksandar and Karagjozov, Panche and Mihailov, Marjan (2022) The predictive role of selective laboratory parameters for the occurance of “unwanted events” in adults with laparoscopic appendectomy. Journal of Morphological Sciences, 5 (1). pp. 64-74. ISSN 2545-4706

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Abstract

The aim of our study was to assess the potential predictive role of selected laboratory parameters in recognition of
laparoscopic appendectomy (LA) associated with unwanted events defined as intraoperative difficulties, conversion to open approach and early postoperative complications. A multicenter, prospective, clinical study was conducted. 75 randomly selected adults
with acute appendicitis were selected as study participants. Twenty five laboratory parameters were measured for all
of them. In 69, LA was performed and in 6 of the patients, a conversion to open appendectomy had to be accomplished. For each patient, we registered the unwanted events in relation to the treatment. Out of 75 participants with LA, 51 (68%) were without and 24 (32%) were with unwanted events. Binary analysis showed significantly higher levels of total bilirubin (p = 0.0228), sodium (p = 0.0161) and C – reactive protein (p = 0.0005) in the group with unwanted events. Multiple logistic regression analysis confirmed the total serum bilirubin as the only independent predictor – OR=1.079[p = 0.041, 95% CI = 1.003-1.162]. High levels of C–reactive protein, serum sodium and total serum bilirubin could be indicators of unwanted intraoperative or postoperative course in the patients treated with LA. In such cases it is wise to consider performing the laparoscopic exploration in the presence of an
experienced surgeon.

Item Type:	Article
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Ilija Milev
Date Deposited:	07 Mar 2023 13:17
Last Modified:	07 Mar 2023 13:17
URI:	https://eprints.ugd.edu.mk/id/eprint/31496

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