Forced degradation of timolol maleate on high temperature for verification of HPLC method for related substances in Timolol eye drop 0.5%

Veleska Stojanovska, Aleksandra and Serafimovska, Tijana and Darkovska-Serafimovska, Marija (2022) Forced degradation of timolol maleate on high temperature for verification of HPLC method for related substances in Timolol eye drop 0.5%. Macedonian Pharmaceutical Bulletin, 68 (1). pp. 199-200. ISSN 1409-8695

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Abstract

Timolol is a potent β-adrenergic blocker, useful in treatment of ocular hypertension or open-angle glaucoma.
Many chromatographic analysis methods have been applied for the determination of pharmaceutical compounds containing heterocyclic rings (as timolol maleate), but the most commonly applied chromatographic technique is HPLC.
Understanding the stability characteristics for both the active pharmaceutical ingredient (API) and for the drug product (DP) is crucial for the development of a safe and effective pharmaceutical agent. For this purpose, samples from API and DP during product development are disposed under strictly controlled storage conditions to assess stability testing. Forced degradation studies are being conducted to identify the degradation products that are likely to occur during long term storage as the worst- case scenario.

Item Type:	Article
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Marija Darkovska-Serafimovska
Date Deposited:	02 Feb 2023 07:25
Last Modified:	02 Feb 2023 07:25
URI:	https://eprints.ugd.edu.mk/id/eprint/31175

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