Evaluation of the in vitro bee venom release and skin absorption from bioadhesive gel formulation

Mircevska, Angela and Ivanoska, Tamara and Mutapcic, Lejla and Shalabalija, Dushko and Mihailova, Ljubica and S. Crcarevska, Maja and Trajchev, Metodija and Nakov, Dimitar and Glavas Dodov, Marija (2020) Evaluation of the in vitro bee venom release and skin absorption from bioadhesive gel formulation. Macedonian Pharmaceutical Bulletin, 66 (03). pp. 221-222. ISSN 1409-8695

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Abstract

Topical and transdermal drug delivery are one of
the most suitable alternative, non-invasive routes for
administration of drugs in clinical practice mainly
due to the increased patient compliance and reduced
systemic drug side effects. Many drug products
applied to the skin surface may penetrate to some
extent into the skin layers, where their effects are
expected, as for example, topical formulations for
the treatment of different local skin disorders. Also,
significant concentrations of drug could be absorbed
by the body regions close to the site of delivery,
where regional effects are expected, for e.g., in the
muscles, local blood vessels and articulations.
Arthritis is a systemic, autoimmune disease
characterized by inflammation of joints.
Inflammatory cytokines cause activation of the
macrophages which leads to swelling of joints,
damage to cartilage, bone erosion , functional
impairment and stiffness. Bee
venom (BV) contains a variety of peptides, including
melittin, apamin, adolapin, the mast-cell
degranulating peptide, enzymes (phospholipase [PL]
A2), biologically active amines (histamine and
epinephrine) and nonpeptide components with anti�inflammatory, anti-arthritis, anticoagulant,
antimicrobial, anticancer and anti-nociceptive
properties. Melittin, a major peptide component of
BV shown to have anti-inflammatory and anti�arthritis properties and inhibitory activity on nuclear
factor kappaB which is involved in the synthesis of
inflammatory mediators and may be essential for the
treatment of arthritis using BV.
The aim of this study was to evaluate the
stability of crude BV as an active ingredient, as well
as to evaluate the in vitro release and skin absorption
of BV from a designed topical gel formulation.

Item Type:	Article
Subjects:	Medical and Health Sciences > Health biotechnology
Divisions:	Faculty of Agriculture
Depositing User:	Dimitar Nakov
Date Deposited:	27 Jan 2023 08:08
Last Modified:	27 Jan 2023 08:08
URI:	https://eprints.ugd.edu.mk/id/eprint/30988

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