Impact of platelet-rich fibrin (PRF) on mandibular third molar surgery recovery: an article review

Denkov, Nikola and Papakoca, Kiro and Longurova, Natasa (2022) Impact of platelet-rich fibrin (PRF) on mandibular third molar surgery recovery: an article review. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), 21 (11). pp. 21-23. ISSN 2279-0853

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Abstract

Background: Extraction of impacted mandibular third molars is the most frequent procedure performed by oral surgeons. This procedure may be associated with considerable postoperative complications including pain, trismus, edema, surgical site infection as well as alveolar osteitis (AO).
Platelet-rich fibrin is characterized by the slow polymerization during its preparation that generates a fibrin network very similar to the natural one that enhances cell migration and proliferation.
Materials and Methods: The aim of this article is to investigated the effect of PRF on lower third molar extraction. Pain, swelling, trismus, alveolar osteitis (AO), and osteoblastic activity were extracted to evaluate the effect of PRF. Also, narrative review of clinical outcomes from different articles published on Pubmed, Medscape, Cochrane Library and Google Scholar are included.
Results: Being a reservoir of platelets, leukocytes, cytokines and immune cells, PRF is reported to allow slow release of cytokines; TGF, PDGF, VEGF, and EGF which play a critical role on angiogenesis and tissue healing and cicatrization. PRF also reported to enhance angiogenesis, support immunity, and to enhance the coverage of injured tissues through its positive effect on epithelial cells and fibroblasts.
Although, PRF preparation is simple, inexpensive process, and requires no additives, rapid blood handling is an important factor in success of its preparation. Failure in quick handling of the blood sample results in a diffuse polymerized fibrin within the glass tube and only a small blood clot without consistency will be obtained.
Conclusion: The evidence supports the use of PRF as socket preservation materials to enhance soft tissue healing and reduce postoperative complications. However, there is no evidence to date to support the positive effect of autologous materialsin hard tissue regeneration.
Keywords: Platelet-rich fibrin, cytokines, alveolar osteitis.

Item Type:	Article
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Natasa Longurova
Date Deposited:	12 Dec 2022 09:11
Last Modified:	12 Dec 2022 09:11
URI:	https://eprints.ugd.edu.mk/id/eprint/30629

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