Synergistic effects of terpenes and cannabinoids evaluated through antimicrobial activity

Cannabis sativa L. (Cannabaceae) is commonly used plant that is considered to have therapeutic potential. Extract obtained from cannabis plants contain cannabinoids as the main carriers of pharmacological effects and terpenes. The hypothesized synergistic interactions between cannabinoids and terpenes to obtain unique pharmacological effects have
been investigated in several preclinical studies. But evidence from preclinical studies whether terpenes can act synergistic with cannabinoids remains unclear with insufficient data. Antimicrobial susceptibility testing of these compounds can be used for prediction of therapeutic outcome.