Radioimmunoconjugates of various monoclonal antibodies as potential anticancer therapy - review

Arev, Marija and Apostolova, Paulina and Janevik-Ivanovska, Emilija (2022) Radioimmunoconjugates of various monoclonal antibodies as potential anticancer therapy - review. Acta medica balkanica - International Journal of Medical Sciences. ISSN 2545-4870

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Radioimmunoconjugates consist of a monoclonal antibody (mAb) linked to a radionuclide. Monoclonal antibodies (mAbs) are immunoglobulins able to recognize unique epitopes on a single antigen. MAbs therapy has emerged as a significant therapeutic choice for different types of cancer. When they contain a radioactive isotope for diagnostic or therapeutic purposes they belong to the group of radiopharmaceuticals. Radioisotopes are atoms that emit radiation and are used based on the type of radiation that is emitted. There are three types of radiation, alpha, beta and gamma radiation. Alpha and beta radiation has a short range and are primarily used for radiotherapy purposes. Gamma radiation, on the other hand, has a wider range, is used for diagnostics, and can be detected using specialized detection systems.
In order to formulate a stable radiopharmaceutical, it is important to provide a stable link between isotope and the carrier molecules (proteins, monoclonal antibodies, peptides, nano-particles). The bifunctional chelators (BFC) contain a metal chelating group on the one side and covalently binding to the biological molecules on the other side. Radioimmunoconjugates are the majority applied radiopharmaceuticals worldwide for diagnostic and therapeutic purposes, and are composed of radioactive element attached to the immune molecules, like monoclonal antibodies. Diagnostic radioimmunoconjugates can be used for body imaging and mostly for identification of positive lesions and metastasis, while radiotherapeutics has shown efficacy in the treatment of solid tumors and hematologic malignancies.

Item Type: Article
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Marija Arev
Date Deposited: 13 Oct 2022 11:02
Last Modified: 13 Oct 2022 11:02

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